SrasV1, Main, Exploration, bibRecord, 000D03

Complemented Palindromic Small RNAs First Discovered from SARS Coronavirus.

Identifieur interne : 000D03 ( Main/Exploration ); précédent : 000D02; suivant : 000D04

Complemented Palindromic Small RNAs First Discovered from SARS Coronavirus.

Auteurs : Chang Liu [République populaire de Chine] ; Ze Chen [République populaire de Chine] ; Yue Hu [République populaire de Chine] ; Haishuo Ji [République populaire de Chine] ; Deshui Yu [République populaire de Chine] ; Wenyuan Shen [République populaire de Chine] ; Siyu Li [République populaire de Chine] ; Jishou Ruan [République populaire de Chine] ; Wenjun Bu [République populaire de Chine] ; Shan Gao [République populaire de Chine]

Source :

Genes [ 2073-4425 ] ; 2018.

RBID : pubmed:30189613

Abstract

In this study, we report for the first time the existence of complemented palindromic small RNAs (cpsRNAs) and propose that cpsRNAs and palindromic small RNAs (psRNAs) constitute a novel class of small RNAs. The first discovered 19-nt cpsRNA UUAACAAGCUUGUUAAAGA, named SARS-CoV-cpsR-19, was detected from a 22-bp DNA complemented palindrome TCTTTAACAAGCTTGTTAAAGA in the severe acute respiratory syndrome coronavirus (SARS-CoV) genome. The phylogenetic analysis supported that this DNA complemented palindrome originated from bat betacoronavirus. The results of RNA interference (RNAi) experiments showed that one 19-nt segment corresponding to SARS-CoV-cpsR-19 significantly induced cell apoptosis. Using this joint analysis of the molecular function and phylogeny, our results suggested that SARS-CoV-cpsR-19 could play a role in SARS-CoV infection or pathogenesis. The discovery of cpsRNAs has paved a way to find novel markers for pathogen detection and to reveal the mechanisms underlying infection or pathogenesis from a different point of view. Researchers can use cpsRNAs to study the infection or pathogenesis of pathogenic viruses when these viruses are not available. The discovery of psRNAs and cpsRNAs, as a novel class of small RNAs, also inspire researchers to investigate DNA palindromes and DNA complemented palindromes with lengths of psRNAs and cpsRNAs in viral genomes.

DOI: 10.3390/genes9090442
PubMed: 30189613

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">In this study, we report for the first time the existence of complemented palindromic small RNAs (cpsRNAs) and propose that cpsRNAs and palindromic small RNAs (psRNAs) constitute a novel class of small RNAs. The first discovered 19-nt cpsRNA UUAACAAGCUUGUUAAAGA, named SARS-CoV-cpsR-19, was detected from a 22-bp DNA complemented palindrome TCTTTAACAAGCTTGTTAAAGA in the severe acute respiratory syndrome coronavirus (SARS-CoV) genome. The phylogenetic analysis supported that this DNA complemented palindrome originated from bat betacoronavirus. The results of RNA interference (RNAi) experiments showed that one 19-nt segment corresponding to SARS-CoV-cpsR-19 significantly induced cell apoptosis. Using this joint analysis of the molecular function and phylogeny, our results suggested that SARS-CoV-cpsR-19 could play a role in SARS-CoV infection or pathogenesis. The discovery of cpsRNAs has paved a way to find novel markers for pathogen detection and to reveal the mechanisms underlying infection or pathogenesis from a different point of view. Researchers can use cpsRNAs to study the infection or pathogenesis of pathogenic viruses when these viruses are not available. The discovery of psRNAs and cpsRNAs, as a novel class of small RNAs, also inspire researchers to investigate DNA palindromes and DNA complemented palindromes with lengths of psRNAs and cpsRNAs in viral genomes.</div>
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Complemented Palindromic Small RNAs First Discovered from SARS Coronavirus.

Complemented Palindromic Small RNAs First Discovered from SARS Coronavirus.

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Abstract

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